Cryptogenic Stroke Initiative

Knowledge is your superpower. 

In about 1 in 3 Ischemic Strokes, the root cause is still unknown after testing. That's why it's important to dig deeper for a definitive diagnosis and potential stroke risk factors. Collaboration by neurologists, cardiologists, electrophysiologists, stroke patients and caregivers and other team members may reveal the answers needed to provide targeted treatment for preventing recurrent strokes.

The ASA’s 2021 Guideline for the Prevention of Stroke in Patients with Stroke and TIA provides new recommendations for the diagnostic workup that physicians should perform.

Our tools are here to help.

masked female patient and doctor

Healthcare Professional Resources

Patient Education Resources

Potential Causes

It's important to consider conditions including (but not limited to):

  • Atrial fibrillation (AF or Afib) – an irregular heartbeat that puts the patient at a 5x greater risk for stroke. Afib may be detected by monitoring the heart's rhythm over time.
  • Patent Foramen Ovale (PFO) – a hole between the heart's chambers that usually closes naturally by adulthood.
  • Hypercoagulable states – blood clotting disorders.
  • Large-artery atherosclerosis – a buildup of fats, cholesterol and other substances in and on artery walls.

Cryptogenic Stroke Collaborative Care Testimonial

Diagnosis and Treatment

A collaborative approach to care can ensure that every stroke patient receives the most thorough care and tailored treatment to prevent recurrent strokes. We've developed resources that can help professionals team up to potentially find the underlying causes.

Stroke Resource Library

Visit the Stroke Resource Library and you'll find stroke prevention, treatment and recovery tools, including handouts, infographics and community education presentations.

Steps to Help Avoid Another Stroke

Clot-related strokes are largely preventable, even if you've already had one. Learn about prevention plans for reducing the risk.


Supports the American Heart Association/American Stroke Association's Cryptogenic Stroke Initiative.